They need to know if you have any of these conditions:

cancer or tumor in abdomen, intestine, or stomach
diverticulitis
history of bowel blockage
history of stomach ulcer
inflammatory bowel disease
kidney disease
liver disease
Ogilvie's syndrome
stomach or intestine problems
an unusual or allergic reaction to naloxegol, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Swallow medicine whole. Do not cut or chew this medicine. The medicine may also be crushed and mixed with 4 ounces of water. Drink immediately after mixing. Take your medicine one time each day, on an empty stomach, at least 1 hour before your first meal of the day or 2 hours after the meal. If you are unable to tolerate your dose, inform your healthcare provider so that your dose can be adjusted. Do not take additional laxatives except on your healthcare provider's advice. Your healthcare provider may prescribe other laxatives if your medicine does not work well enough after 3 days of treatment. Tell your healthcare provider if you stop taking your pain medicine. If you stop taking your pain medicine, you should also stop taking this medicine. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
new or worsening stomach pain
severe or prolonged diarrhea
signs and symptoms of opioid withdrawal such as sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

diarrhea
headache
nausea
stomach gas
stomach pain
vomiting

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Keep out of the reach of children.

This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law. Follow the directions in the MedGuide.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.